NEPHRON+ ICT-enabled Wearable Artificial Kidney and Personal Renal Care System


The EU project „NEPHRON+“ aims at developing a novel system for renal replacement therapy. The eponym of this project is the nephron, the smallest functional subunit of the kidney.
The artificial kidney shall be compact to the point that it is wearable by the patient in his daily life. With integrated sensors the system automatically monitors the most important parameters of the patient and adjusts the treatment due to the measured values. The data is saved and serves the treating physician as a follow-up.

Technical and medical specialists from various countries are involved in the EU-wide project. OFFIS part in this project is to develop an embedded software that varies from efficient algorithms to save and evaluate blood values and sensor data up to the control of the hardware with a suited operating system. With this, a secure and efficient function of the whole system is enabled and the core requirements for medical devices are met.

In 2007, the number of end stage renal disease patients was about 1.5 million. In Europe this is added by 4 % every year. 90 % of these patients are dependent on dialysis. But the dialysis treatment demands periodic hospitalizations. Furthermore, there are long gaps between treatments which burden the patient. With innovative technologies, a new system shall be developed that abolishes the deficits of conventional dialysis therapy.

Gründe für die Virtualisierung eingebetteter Systeme

Frank Poppen; iX Developer; 02 / 2014

Virtual Prototype of a Personal Medical Device – Simulation of a Multi Nature System

Pielawa, Lukas and Poppen, Frank and Hein, Andreas; 002 / 2011

Physiologische Überwachung in der Nierenersatztherapie

Pielawa, Lukas and Hein, Andreas; 009 / 2010

Online Adaptive Physiological Models for Dialysis Therapy

Pielawa, Lukas and Brell, Melina and Hein, Andreas; Biomed Tech; 006 / 2011

Nephron+ Wearable Artificial Kidney

F. Simonis, C. Kotsokalis, J. Boomker, L. Pielawa, M. Brell, F. Poppen, M. Simonis, S. Wiegersma, A. Boersma, M. Ivan, A. Raptopoulos, M. Correvon, G.Dudnik, M. Schneider, H. Anis, F. Meyering, J. Fils, G. Marchand, J. Hartmann, M. Wester, J.A. Joles, P. ; 10 / 2011

Heterogeneous Assertion-Based Verification for Medical Devices Development

Laemmermann, Stefan and Pielawa Lukas and Burger, Andreas and Schlemminger, Jan and Ruf, Juergen and Kropf, Thomas and Hein, Andreas and Rosenstiel Wolfgang; 003 / 2012

Co-Simulation of C-based SoC Simulators and MATLAB Simulink

Poppen, Frank and Grüttner, Kim; 003 / 2012

Model-Based Physiological Data Stream Evaluation for Dialysis Therapy

Pielawa, Lukas and Wester, Maarten and Simonis, Frank and Hein, Andreas; 006 / 2012

Integrated Monitoring for Personalized Renal Replacement Therapy

Pielawa, Lukas and Poppen, Frank and Wester, Maarten and Simonis, Frank and Brell, Melina and Joles, Jaap and Hein, Andreas; 009 / 2012

Mobile Dialyse für mehr Lebensqualität

Pielawa, Lukas and Brell, Melina and Hein, Andreas; inno; 006 / 2012

Centre Suisse d'Electronique et de Microtechnique S.A.
Nederlandse organisatie voor toegepast natuurwetenschappelijk onderzoek TNO
Nanodialysis BV
Donau-Universität Krems
University Medical Center Utrecht


Start: 31.03.2010
End: 30.03.2014

Website of project